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Why people use it
Holy basil, or tulsi, is a sacred Ayurvedic herb also cooked across Southeast Asia. Small human studies have explored stress, blood sugar and immune measures, and a recent extract trial reported lower perceived stress, but the World Health Organization lists no use supported by clinical data and the pregnancy caution rests on animal studies.
- ✓Ayurvedic and Siddha traditional herb for stress and resilience
- ✓Daily tea and courtyard devotional plant in India
- ✓Thai and Southeast Asian cooking (kaphrao)
- ✓Small trials on stress, glucose and immune markers
02
What the evidence says
A 2017 systematic review found 24 small human studies on metabolic, stress and immune outcomes, all reporting favorable results with no significant adverse events, but the studies were heterogeneous in preparation and often unblinded. The WHO monograph states that no use is supported by clinical data. A 2022 industry-funded randomized trial of one standardized extract reported lower perceived stress and smaller blood-pressure rises under acute stress, and a 1996 crossover trial of leaves showed a modest fall in fasting glucose.
Hover, focus or tap each label for context.
These labels summarize the available context; they are not a clinical recommendation.03
Common forms
Hover, focus or tap a form to see what it means.
Tea, powder, standardized extract and essential oil are different exposures. Study findings apply only to the preparation tested, and essential oil safety is unrelated to leaf safety.
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Traditional and practitioner context
Ocimum tenuiflorum is traditionally used in Ayurveda and Siddha medicine, where it is often called the elixir of life, in preparations for fever, cough, cold and digestive complaints, and the WHO monograph records a traditional decoction of crude leaf. In Hindu households tulsi is cultivated in the courtyard and used in daily worship, a practice widely documented in ethnobotanical literature. In Thailand the same species, kaphrao, is the herb of pad kaphrao stir-fries, and it is known as kemangi or selaseh in Indonesia and Malaysia.
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Foraging index
Garden and container plant in North America
USDA PLANTS records holy basil as introduced only in Puerto Rico and the Pacific Basin, with no wild record in the continental United States; it is a garden and container plant here. Do not confuse it with sweet basil or Thai basil (Ocimum basilicum), whose oils are methyl chavicol and linalool types, or with African clove basil (Ocimum gratissimum), which is sometimes sold as tulsi.
Status: cultivation only. Broad occurrence never confirms identity, safe use, legal access or permission to harvest.
Read the responsible foraging guide →Safety note
Know before you use it
Reproductive caution: feeding high doses of leaf or solvent extracts to rats and mice reduced fertility and prevented implantation, and the WHO monograph lists pregnancy and breastfeeding as contraindications on that animal basis; no human data exist either way, so avoid medicinal amounts when pregnant, breastfeeding or trying to conceive. One small trial found leaves lowered fasting glucose, so monitor blood sugar if you use insulin or oral diabetes medicines, and watch blood pressure with concentrated extracts. Eugenol in the leaf can strain liver glutathione in animals, so use caution with acetaminophen (paracetamol). Never swallow tulsi essential oil or apply it undiluted. If you take prescription medicines, are pregnant or breastfeeding, or are preparing for surgery or a procedure, review supplement or concentrated-product use with a qualified clinician or pharmacist before starting it.
Read the complete Holy basil (tulsi) guide
Valerian, passionflower, rhodiola, bacopa and tulsi are often sold together as calm-and-focus supplements. Their traditions, evidence and safety profiles are not the same.
Open the full guideQuestions about Holy basil (tulsi)
Sources & review
- Folium Ocimi Sancti, in WHO Monographs on Selected Medicinal Plants, Volume 2World Health Organization
- The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review (Jamshidi and Cohen, 2017)Evidence-Based Complementary and Alternative Medicine / PubMed
- Randomized placebo-controlled single-blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus (Agrawal et al., 1996)International Journal of Clinical Pharmacology and Therapeutics / PubMed
- A randomized, double-blind, placebo-controlled trial of an Ocimum tenuiflorum extract on stress, mood and sleep (Lopresti et al., 2022)Frontiers in Nutrition / PubMed
- Comparative study of eugenol and Ocimum sanctum leaf extract on antifertility effect in female albino rats (Poli and Challa, 2019)Journal of the Chinese Medical Association / PubMed
- Seasonal variation in essential oil composition of three Ocimum species from Nepal (Paudel et al., 2025)Molecules / PubMed
- USDA PLANTS profile: Ocimum tenuiflorum (OCTE2)USDA Natural Resources Conservation Service
